Repositories and other initiatives

In this section, we are studying data sharing platforms, repositories and indeed any other initiative.

STATUS OF SHARING OF INDIVIDUAL PARTICIPANT DATA FROM CLINICAL TRIALS, USE OF SHARED DATA AND IMPACT OF RESEARCH OUTPUTS OF SHARING DATA

To explore the impact of early clinical trial data initiatives in terms of five outcome domains: status of intent to share data, status of data sharing, use of shared data and impact of research outputs from shared data.
Protocol / Paper

ATTENTION AND IMPACT OF SHARING INDIVIDUAL PARTICIPANT DATA FROM CLINICAL TRIALS: A CROSS SECTIONAL ANALYSIS OF PUBLISHED RE-USE FROM 3 MAJOR REPOSITORIES

Randomized clinical trials data sharing policies should have an evaluation component. Our main objective was to assess the impact of published re-uses from RCTs using media attention (Altmetric) and citation rates.

Protocol / Paper

INFERENTIAL REPRODUCIBILITY OF THERAPEUTIC RESEARCH: A CROSS-SECTIONAL STUDY OF RANDOMIZED CONTROLLED TRIALS AVAILABLE ON MAJOR DATA-SHARING PLATFORMS

This registered report introduces a cross-sectional study aiming to assess inferential reproducibility (qualitatively similar conclusions can be drawn from a reanalysis of the original trials) for main RCTs available on major data-sharing platforms.

Protocol / Work in progress, in principle acceptance at Royal Society Open Science

IMPLEMENTING CLINICAL TRIAL DATA SHARING REQUIRES TRAINING A NEW GENERATION OF BIOMEDICAL RESEARCHERS

A policy forum "Implementing clinical trial data sharing requires training a new generation of biomedical researchers" proposes an agenda that aims to train a new generation of experts for clinical trial data sharing.

Paper / Detailed project

TEN (NOT SO) SIMPLE RULES FOR CLINICAL TRIAL DATA-SHARING

We propose 10 (not so) simple rules for researchers wishing to share data, aligned on the clinical trial lifecycle. These rules cover the majority of elements to be considered in order to start the commendable process of clinical trial data-sharing.
Paper

MAKING DATA-SHARING THE NORM IN MEDICAL RESEARCH

In this editorial, we comment on the low data sharing rates observed in the biomedical literature. We discuss the scientific and ethical value of clinical trial data sharing and call various stakeholders to act in order to make clinical trial data sharing a norm for biomedical research.

Paper