Reproducibility

Concerns about the reproducibility of research had been rising. In this section we study various features of research reproducibility in therapeutic research.

VIBRATION OF EFFECTS FROM DIVERSE INCLUSION/EXCLUSION CRITERIA AND ANALYTICAL CHOICES: 9216 DIFFERENT WAYS TO PERFORM AN INDIRECT COMPARISON META-ANALYSIS

Different methodological choices such as inclusion/exclusion criteria and analytical models can yield different results and inferences when meta-analyses are performed. We explored the range of such differences, using several methodological choices for indirect comparison meta-analyses to compare nalmefene and naltrexone in the reduction of alcohol consumption as a case study. Protocol / Paper

PERFORMING A LARGE NUMBER OF OVERLAPPING META-ANALYSES ASSESSING ACUPUNCTURE EFFICACY FOR SMOKING CESSATION TO EXPLORE VIBRATION OF EFFECTS

Different methodological choices such as inclusion/exclusion criteria and analytical models can yield different results and inferences when meta-analyses are performed. We are exploring the range of such differences, using several methodological choices for meta-analyses to compare acupuncture and controls in smoking cessation as a case study.
Protocol / Paper

VIBRATION OF EFFECTS IN POOLED ANALYSES OF RANDOMIZED CONTROLLED TRIALS COMPARING CANAGLIFLOZIN VERSUS PLACEBO IN TYPE 2 DIABETES MELLITUS

Different combinations of randomized controlled trials can yield different results and inferences when pooled analyses are performed. We are exploring the range of such differences, using all possible combinations of studies for pooled analyses to compare canaglifozin and placebo in type 2 diabetes mellitus.

Protocol / Paper

VIBRATION OF EFFECS RESULTING FROM NETWORK GEOMETRY IN MIXED-TREATMENT COMPARISONS: CASE STUDY IN MAJOR DEPRESSIVE DISORDER

To apply the vibration of effect framework for examining the range of treatment effects that can be obtained in mixed treatment comparisons of antidepressants in major depressive disorders when considering all possible combinations of overlapping networks.
Protocol / Preprint

THE USE OF THE REGISTERED REPORT FORMAT FOR PUBLICATION OF CLINICAL TRIALS : A CROSS-SECTIONAL STUDY

Because of the coherence of the requirements of the "registered reports" format with the confirmatory nature of randomised controlled (RCTs) trials, we aimed to identify and describe RCTs published as Registered Reports.

Protocol / Preprint / Paper

QUALITY, TRANSPARENCY AND REPRODUCIBILITY OF THE CLINICAL DEVELOPMENT OF KINASE INHIBITORS IN ONCOLOGY

To describe the characteristics of kinase inhibitor dose escalation trials performed in the oncology field; and to characterize the level of transparency and reproducibility of this literature.
Protocol / Work in progress

IMPROVING THE TRANSPARENCY AND RELIABILITY OF OBSERVATIONAL STUDIES THROUGH REGISTRATION

Routine registration of observational research is needed and we suggest how current processes can be adapted to facilitate it.